Fig. 1

A Schematic representation of the complete NxtDRP model pipeline. B Representative dose-response curve illustrating the definition of IC50 and the Area Under the Dose-Response Curve (AUDRC). C Data splitting strategies employed for model evaluation: Random Splits, Unseen Cell Lines, and Unseen Drugs (red cells indicate the test set). D Distribution of IC50 values derived from the GDSC dataset. E Distribution of individual IC50 values normalized by their corresponding drug’s mean IC50. F Distribution of individual IC50 values normalized by their corresponding cell line’s mean IC50. G Individual IC50 values relative to the maximum drug concentration tested in each cell viability experiment. All IC50 values are expressed on the natural logarithm (ln) scale